Registered Nurse Jobs in Saint Louis, MO

Registered Nurse Job Market in Saint Louis, MO (2026)

The Registered Nurse job market in Saint Louis, MO is moderately active, with 191 open positions across 15+ employers. Hiring momentum is strong, with 31 new listings in the past month and 19 in the last week alone.

What Can You Expect to Earn?

The median salary for Registered Nurse roles in Saint Louis, MO is $87,277, with most positions paying between $76,615 and $87,277. Top performers can earn $105,600 or more at the 90th percentile. Note that 95% of listings in this market don't disclose salary, so actual compensation varies — especially for negotiable roles. For higher compensation, consider Tyler, TX where the median is $400,000.

Skills That Employers Want

Analysis of job descriptions in Saint Louis, MO shows the most requested skills are Nursing, Patient Care, BLS, CPR, Customer Service, and EHR. Including these keywords in your resume can significantly improve your ATS match rate. Our Registered Nurse resume example shows how to integrate these naturally.

Who's Hiring?

The most active employers for Registered Nurse positions in Saint Louis, MO include ATC Marietta, Veterans Affairs, Veterans Health Administration, Bestica, ScionHealth, and Healthforce. Use JobsChat AI to filter by specific companies or discover employers that match your preferences.

Ready to Apply?

Start with our Registered Nurse resume example. Pair it with a tailored cover letter. Then use JobsChat AI to search all 191 positions and generate application materials in minutes. Browse Registered Nurse jobs in other cities or explore all jobs in Saint Louis, MO.